July is heating up and the bugs are showing up in droves.  My biggest challenge this time of year is keeping weeds knocked back and breaking the life cycle of destructive pests.  
1.  Weeds:  The best weed defense is prevention.  This is akin to cancer screenings like colonoscopies and mammograms.  Prior to July be sure you are tarping, mulching, and hoeing.  However, if you missed the memo then grab a weedeater, tarp or heavy landscape fabric, and a hoe.  Weedeat grass patches and cover with a tarp or fabric.  The heat will kill off weeds and grass in two weeks.  In areas you can't weedeat because of your plants use a sharp hoe ( check out J0hnny's Seeds Connecta Cultivation Kit).  It is also probably good to recognize in the southeast that you WILL have weeds. Period. 
2.  Pests:  Japanese beetle control- bucket of sudsy water about 1/3 full.  Go out in early morning and knock them into bucket when they are asleep.  Beetlebegone is also a beetle specific organic control that does not effect bees, butterflies, and lady bugs which are all beneficial insects.  
Bean Beetles- at this time of year they show up as little yellow larvae that look furry.  Your best bet is to squish them which is actually kind of satisfying in a saddistic way :) but you can also use BT ( bacillus thuringiensis). The problem with BT is that it is non-specific and will kill any soft bodied bug.  
Pumpkin bugs- squish them and kill the eggs.  They are little clusters of brown eggs and are typically on the underside of the leaves.  Put a board under your squash and then turn it over in morning and toss them in sudsy water or catch them with duct tape aroung your hand.  Diatomaceous earth is an organic dust that you can sprinkle right on the bugs.
Vine Borers- good luck.  Wedding veil row cover (can be purchased at wal-mart fairly cheap) early in the season is a great prevention.  BT sprayed around the base of the plant every day seems to help, and diatomaceous earth sprinkled around the base helps.  
Leaf legged bugs- the absolute bane of my tomato existence.  Hand held vacuum cleaner is a great control and kind of fun.  Diatomaceous earth dusted just on the actual tomato helps a great deal.